Eoin Morgan will miss the one-day international tour of India after being ruled out for three months by a shoulder injury.
He will undergo surgery on his right shoulder, aiming to return for the matches against Pakistan in the winter.
The left-hander, 24, first suffered the problem last winter and it returned in last month's Twenty20 game with India.
On Tuesday, it was confirmed that Morgan would miss the rest of the home one-day series against India.
The Dublin-born batsman was England's one-day captain against Ireland last month.
ECB chief medical officer Dr Nick Peirce said in a statement: "After seeing a specialist, it has been confirmed that Eoin will require surgery to his right shoulder.
"We have managed the injury to date but Eoin has now reached the stage where surgery is the most appropriate progression of his treatment.
"Following the operation Eoin will undertake a rehabilitation programme ruling him out of all cricket for approximately 12 weeks.
"The recovery period is anticipated to see him return to full fitness ahead of England's tour of the UAE commencing in January."
