Leo Cullen will captain an Ireland side that features 10 changes, one positional, for the Pool C match against Russia on Sunday.
Lock Cullen is one eight Leinster players in the team, including fellow World Cup debutants, hooker Sean Cronin and winger Fergus McFadden.
Munster flanker Donnacha Ryan is also playing his first match in the event.
Coach Declan Kidney elected to rest most of his senior players ahead of next week's match with Italy.
Among those stood down are regular captain Brian O'Driscoll, Gordon D'Arcy, Paul O'Connell and Tommy Bowe, the latter trio all carrying injuries after the 15-6 victory over Australia which has left the Irish favourites to clinch top spot in Pool C and seal a quarter-final place.
Ireland manager Paul McNaughton had hinted Kidney would not make wholesale changes, but Kidney explained: "I think in tournament rugby it's extremely difficult to play in games non-stop.
"These guys who are playing here have been training very well, and I think they're the best men to represent us in this match."
Other changes see Jonathan Sexton drop to the bench to allow Ronan O'Gara to start at fly-half, while Keith Earls switches from wing to centre to partner Paddy Wallace, who is finally rewarded with his first World Cup start in his third appearance at the tournament.
The Ulster midfielder was unused in 2003 and only played three minutes - against Namibia - in 2007.
"I always say to the lads, the easiest job here is playing one to 15. The difficult job is not being in the starting 15," Kidney added.
"What Paddy has contributed would be an example for every young player coming through of how to give to the squad without always wanting yourself.
"He's been as disappointed as any man I've ever left off, but he always takes some time for himself then comes back and feeds it back into the team."
The back row duo of number eight Jamie Heaslip and open-side Sean O'Brien retain their places, while hooker Sean Cronin and tight-head Tony Buckley come into the front row alongside Cian Healy, with Rory Best and Mike Ross dropping to the bench.
Cullen will become the third Irishman to be skipper in his tournament debut after Donal Lenihan in 1987 and Dion O'Cuinneagain in 1999.
"There's a real buzz in the camp," he said. "I think for the guys that are playing this week there's a massive responsibility to carry on that momentum we have."
He and Ronan O'Gara are the only survivors from Ireland's only previous match with Russia nine years ago, a 35-3 win in Krasnoyarsk in a qualifier for the 2003 World Cup.
"I remember getting off the plane and we had three or four supporters there, and my old man was one of them," Cullen added. "He's back again for the trip this week."
IRELAND V RUSSIA FACTS
Ireland defeated Russia 35-3 in their only previous meeting in 2002
Russia are playing in their first Rugby World Cup
The Soviet Union played its first official international in 1974
Ireland team: Rob Kearney, Fergus McFadden (both Leinster), Keith Earls (Ulster), Paddy Wallace, Andrew Trimble (both Ulster), Ronan O'Gara (Munster), Isaac Boss; Cian Healy, Sean Cronin (all Leinster), Tony Buckley (Sale), Donncha O'Callaghan (Munster), Leo Cullen (captain, Leinster), Donnacha Ryan (Munster), Sean O'Brien, Jamie Heaslip (both Leinster).
Replacements: Rory Best (Ulster), Mike Ross (Leinster), Denis Leamy (Munster), Shane Jennings, Eoin Reddan, Jonathan Sexton (all Leinster), Geordan Murphy (Leicester).
