Manchester United goalkeeper David de Gea is not expected to feature after suffering a knee injury before the Europa League loss to FC Midtjylland.
He became the 14th player on United's injury list, which includes captain Wayne Rooney,
Shrewsbury's former Manchester United midfielder Larnell Cole returns to the squad after three games out with a groin injury.
Manager Micky Mellon also confirmed defender Jack Grimmer will be fit.
"We will give it our best go and we won't be overawed.
"We will make sure that we thoroughly enjoy the game and take it all in and give the best account of ourselves that we possibly can to represent this great football town.
"We've got to do certain things in a certain way to increase our chances of getting a result, so that's what we're working on and the mentality we're approaching the game with."
Manchester United manager Louis van Gaal admitted "You cannot continue with losing games," whose side were on the wrong end of results against Sunderland and Danish side Midtjylland in their last two outings.
"You have to see every match as a match you have to win. On Monday, we have to win.
"If we win, we are in the next round and we are capable of winning The FA Cup."
Date: Monday, 22 February
Kick-off: 19:45 GMT