Rafael dos Anjos has reportedly been forced to pull out of his Las Vegas bout with Conor McGregor due to a foot injury.
Featherweight champ McGregor was due to face top lightweight Dos Anjos in Vegas on 5 March in a bid to become the first UFC fighter to hold belts at two divisions simultaneously.
However, multiple sources claim Dos Anjos will not be fit for the hugely anticipated UFC 196 showdown.
Last July Jose Also withdrew from a title fight with the Dubliner at the MGM Grand Garden Arena with a rib injury, being replaced at the last minute by Chad Mendes.
It remains to be seen whether the UFC will find an opponent for McGregor this late in the day, as the 27-year-old now faces the prospect of again fighting for an interim belt.
McGregor was vowing to become a two-weight UFC champion with victory, after securing the featherweight title in sensational fashion when he finally fought Aldo in December.