|Zidane at press conference, Madrid|
The striker went off with a knee injury in the first leg and missed Saturday's 4-0 league win over Eibar.
Real coach Zinedine Zidane has urged his side to be patient at the Bernabeu.
"There are a lot of messages about firing ourselves up but we need the opposite - we have to use our heads," said Zidane.
"We're not going to win the game in 10 or 15 minutes, and they could really complicate things if they score a goal.
"Wolfsburg are going to start with intensity and we need the same intensity and it's going to be decided with the ball, how much we fight and run.
"Everyone is going to do that but the most important thing is we play football."
Gareth Bale and midfielder Toni Kroos did not play against Eibar and are expected to start, along with centre-back Sergio Ramos, who was suspended.
"I don't need to say too much to the players because they know exactly what's at stake," added Zidane, who scored the winner when 10-time champions Real won Europe's top competition in 2002.
"I've seen the faces of the players, they're very focused on the game and that's the most important thing."
Wolfsburg drew 1-1 with Mainz last weekend in a result which left them eighth in the Bundesliga and effectively ended their hopes of qualifying for next season's Champions League via a high league placing.
"Everyone knows we are not playing perfectly in our own league but we are doing very well in the Champions League," said Wolfsburg coach Dieter Hecking.
"We had a great start in the first game and it is not being arrogant to say we can qualify.
"We knew we needed two magnificent days, we already had one and now we need another one.
"Over the two games Real Madrid are still favourites, but our task is for the favourites to fail."