Fulham are without forward Bryan Ruiz after he suffered a suspected broken foot against Bolton.
They will again assess the fitness of Pavel Pogrebnyak, while Danny Murphy could also return after illness.
Chelsea will again be without left-back Ashley Cole, so Ryan Bertrand will deputise.
Michael Essein is also missing, but Frank Lampard and John Terry, who all missed the win over Wigan, are fit again.
The performances of these two teams on Saturday would suggest that Fulham could be set for only their second victory against Chelsea in 32 league and cup meetings spanning 32 years.
The Cottagers looked very impressive at Bolton in their joint best ever Premier League away victory, while Chelsea were labouring to their win against Wigan courtesy of two poor calls from the assistant referee.
They've already pushed Chelsea hard twice this season and if Pavel Pogrebnyak is fit they will have enough goal threat to worry Chelsea, who will have tired legs as their busy fixture list takes its toll.
Clint Dempsey scored in the Boxing Day draw between the sides at Stamford Bridge and now has a career best 21 goals this season. He is now attracting the attention of top European sides. Chelsea will need to be wary of his movement off defenders in the box.
Roberto di Matteo, with eight wins from 10 games in charge, will make changes to freshen up his side. Fernando Torres is set to replace Didier Drogba but if Fulham stick to surely their best back four (Stephen Kelly, Aaron Hughes, Brede Hangeland and John Arne Riise) he won't find it any easier to score.
Branislav Ivanovic, with three goals in their last two league games, has scored as many as Fernando Torres has all season.
His form is turning though and if Frank Lampard, who has netted eight Chelsea goals against Fulham, returns from injury the visitors will also carry real scoring threat.
They simply can't afford defeat. It would put a serious dent in their hopes of a top four place. Fulham's need isn't as pressing, but their home form is solid with just two defeats in twelve games.
