Andy Robinson has selected six uncapped players in Scotland's 36-man squad for the Six Nations campaign.
Edinburgh's Lee Jones and the Glasgow trio of Stuart Hogg, Duncan Weir and flanker Robert Harley make the list.
Sale Sharks lock Fraser McKenzie and London Irish centre Steven Shingler are also included.
All 28 available players from the Rugby World Cup squad are named, but Johnnie Beattie misses out.
The Scots will be without the kicking prowess of Chris Paterson, who has retired from international rugby, ahead of the Six Nations opener at home to England on 4 February.
Swansea-born Shingler qualifies for Scotland through his Dumfries-born mother.
"I would be massively proud to play for Scotland," said Shingler. "My upbringing from my mother means I've always known about Scotland.
"I've got my gran, auntie, two uncles and two cousins in Langholm and other than the past year I've been up 15 years on the bounce to see them around the time of the Common Riding and I've competed in the Games as well."
Veteran fly-half Dan Parks and wing Simon Danielli both made the squad, but Glasgow Warriors's number eight Beattie missed out.
The number eight berth was one of several key problem positions where Robinson was facing tough decisions, paving the way for Denton to impress at international level.
No announcement was made on the captaincy - currently held by Al Kellock - but flankers John Barclay and Kelly Brown and hooker Ross Ford are all vying for the role.
Scotland will be looking for a positive Six Nations campaign following the disappointment of the World Cup, where they were eliminated at the group stage for the first time.
"I am pleased to reflect on the winning displays we have seen from both Edinburgh Rugby and Glasgow Warriors over the last two months and the contribution a number of our uncapped players have made to them," said Robinson.
"I think what's also encouraging is that a number of players who have forced their way into contention in that period and who have not made the squad this time, are really knocking on the door and that competition for places can only raise our standards, so this Scotland squad can be very much a work in progress over the coming months.
"We said after the Rugby World Cup that the challenge the Scotland squad must confront is to get on with the business of winning international rugby matches."
The squad will gather at St Andrews on Monday 23 January, before being trimmed ahead of the Six Nations opener against England.
Full Scotland squad for RBS 6 Nations:
Backs: J Ansbro (London Irish), M Blair (Edinburgh), C Cusiter (Glasgow Warriors), S Danielli (Ulster), N De Luca (Edinburgh), M Evans (Castres), S Hogg, R Jackson (both Glasgow Warriors), L Jones, G Laidlaw (both Edinburgh), R Lamont (Glasgow Warriors), S Lamont (Scarlets), R Lawson (Gloucester), G Morrison (Glasgow Warriors), D Parks (Cardiff Blues), S Shingler (London Irish) and D Weir (Glasgow Warriors). Forwards: J Barclay (Glasgow Warriors), K Brown (Saracens), G Cross, D Denton (both Edinburgh Rugby), A Dickinson (Sale Sharks), R Ford (Edinburgh Rugby), R Gray, D Hall (both Glasgow Warriors), J Hamilton (Gloucester), R Harley (Glasgow Warriors), A Jacobsen (Edinburgh), A Kellock (Glasgow Warriors), S Lawson (Gloucester), M Low (Glasgow Warriors), F McKenzie (Sale Sharks), E Murray (Newcastle Falcons), R Rennie (Edinburgh Rugby), A Strokosch (Gloucester) and R Vernon (Sale Sharks).
