Emanuel Steward, who trained legendary fighters Thomas Hearns, Lennox Lewis and Wladimir Klitschko among many others, has died at the age of 68.
He made his name as a trainer at the Kronk gym in Detroit, where Hearns first became world champion in 1980.
The American handled more world champions than any other trainer, 43 in all, and was working with current heavyweight champion Klitschko in July.
"Boxing has suffered a tremendous loss," said Klitschko.
"Rest in peace Emanuel. You will be greatly missed."
Steward, who had been suffering from colon cancer, also trained boxing greats Wilfred Benitez, Julio Cesar Chavez, Oscar de la Hoya, Evander Holyfield, Mike McCallum and James Toney.
In addition to Lewis, other British fighters coached by Steward, who was inducted into the International Hall of Fame in 1996, include former light-heavyweight world champion Dennis Andries and former featherweight world champion Naseem Hamed.
Promoter Frank Maloney, who managed former world heavyweight champion Lewis, said Steward was unique in style.
"He was quite a character," he told BBC Radio 5 live. "He had a very strange method of doing his training programme, but got the best out of Lennox Lewis and took him to a new level.
"I also saw him work with Naseem Hamed and he was a great believer in the fighter having to be excited, and having to knock people out. He wasn't really into the science of boxing, more the excitement, and giving the crowd what they wanted."
Ten-time world champion De la Hoya, who trained under Steward in 1997, said: "It brings me great grief and sadness to hear of the passing of one of the best and most respected trainers of this era.
"I learned a lot from him during our professional relationship and I will be forever grateful for his help during that time.
"We were also friends and I know I am going to miss him as so many others will too. He was an important part of our boxing community."
Freddie Roach, who trains multiple world champion Manny Pacquiao, said on Twitter
Emanuel Steward passing today is the biggest loss to boxing in a long time. He'll be greatly missed. My thoughts and prayers are with his family."
As an amateur boxer, Steward won 94 of his 97 fights and a National Golden Gloves bantamweight title in 1963, before becoming a trainer.
He was perhaps most closely associated with Hearns, whom he first trained as an amateur at the fabled Kronk.
In March 1980, Hilmer Kenty became Steward's first pro world champion when he won the WBA lightweight crown, also becoming the first world champion from Detroit since heavyweight great Joe Louis decades earlier.
Under Steward, Hearns became the first boxer to win world titles in five weight divisions and engaged in classic fights with Sugar Ray Leonard, Roberto Duran and Marvin Hagler.
Steward linked up with Lewis following the British heavyweight's defeat by Oliver McCall in 1994 and the partnership endured until Lewis's retirement in 2004.
Steward was immediately enlisted by Klitschko and, having lost his WBO belt to Corrie Sanders in 2003, the Ukrainian became world champion again in 2006.
The duo worked together until July when Steward became ill, leaving Klitschko to train without Steward for his fight against Mariusz Wach next month in Germany.
"His spirit is always here," Klitschko said. "I can hear his voice in sparring while doing things, whispering in my ear. As the famous saying goes 'the show must go on', and that's exactly the case."
