Stuart Lancaster is expected to name Mako Vunipola, Tom Youngs, Courtney Lawes and Tom Wood in his 32-man squad on Thursday for England's autumn Tests.
The England head coach is being forced into changes by injuries to Ben Foden, Tom Croft, Alex Corbisiero and Rob Webber, and the retirement of Charlie Hodgson, Matt Stevens and Lee Mears.
England face Fiji, Australia, South Africa and New Zealand at Twickenham.
Lawes and Wood are fit after being injured for the South Africa tour.
Saracens prop Vunipola, 21, is set to take the place of Corbisiero in the squad, having represented England at Under-18 and Under-20 levels.
London Irish player Corbisiero needed surgery on a knee injury sustained in South Africa in the summer.
Leicester's Youngs, 25, is likely to take over from Webber as cover for Northampton's Dylan Hartley.
Northampton full-back Foden is out with a damaged ankle, while Leicester's Croft is out with a neck injury.
Bath's Webber is recovering from a shoulder problem.
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