Saracens welcome back England centre Brad Barritt for the Heineken Cup quarter-final with Clermont Auvergne.
Fit-again England scrum-half Richard Wigglesworth makes his first start since October, while Wales prop Rhys Gill also returns.
Clermont, like Saracens currently second in their domestic league, bring in fly-half David Skrela to partner Morgan Parra in the halves.
Wales' Lee Byrne joins ex-All Black Sitiveni Sivivatu in the back three.
Saracens director of rugby Mark McCall said: "Competing with the elite of Europe in the knockout stages of tournaments is where we want to be… both now and in the future.
"If you look at the likes of Toulouse, Leicester Tigers, Leinster and Munster, these are teams who have created a legacy in Europe. We want to do the same.
"But we know the size of the challenge in front of us. Looking through the Clermont squad, you will see a number of very familiar names from both the club and world stage. It's a massive game and the kind of contest that we relish!"
Team news
Saracens: 15. Alex Goode, 14. David Strettle, 13. Owen Farrell, 12. Brad Barritt, 11. Chris Wyles, 10. Charlie Hodgson, 9. Richard Wigglesworth, 1. Rhys Gill, 2. Schalk Brits, 3. Matt Stevens, 4. Steve Borthwick (capt), 5. Mouritz Botha, 6. Justin Melck, 7. Will Fraser, 8. Ernst Joubert.
Replacements: 16. Jamie George, 17. Mako Vunipola, 18. Carlos Nieto, 19. George Kruis, 20. Jackson Wray, 21. Neil de Kock, 22. Adam Powell, 23. James Short.
Clermont Auvergne: 15. Lee Byrne, 14. Sitiveni Sivivatu, 13. Wesley Fofana, 12. Aurélien Rougerie (capt), 11. Julien Malzieu, 10. David Skrela, 9. Morgan Parra, 1. Lionel Faure, 2. Benjamin Kayser, 3. Davit Zirakashvili, 4. Jamie Cudmore, 5. Nathan Hines, 6. Julien Bonnaire, 7. Alexandre Lapandry, 8. Elvis Vermeulen.
Replacements: 16. Ti'i Paulo, 17. Vincent Debaty, 18. Daniel Kotze, 19. Julien Pierre, 20. Julien Bardy, 21. Ludovic Radoslavjevic , 22. Brock James, 23. Jean-Marcel Buttin.
